The Improved Cytotoxic Capacity of Functionalized Nanodiamonds with Metformin in Breast and Ovarian Cancer Cell Lines

Nanodiamonds (ND-COOH) are used as drug delivery systems because of their attractive properties, they allow for optimized transport therapeutic agents in cellular models. Metformin (MET) is a diabetes mellitus therapy and exhibits anti-cancer properties. In this study, dispersed nanodiamonds were functionalized with metformin by directly binding them to 1,6-hexanediol (ND-MET), effects on the cytotoxicity breast ovarian cancer cells evaluated vitro. A simple synthesis ND-MET was performed characterized using FT-IR, XPS, Boehm titration, RAMAN, XDR, TEM, dynamic light scattering (DLS). Data showed an increased intensity C-N bond band, indicating presence ND-MET. We detected signals at 1427 cm−1 1288 corresponding C-H bonds, adsorptions 1061 3208 N-O N-H respectively. The deconvolution C1s energy also found 286.24 eV. biological tested both SKOV3 Hs-578T MDA-MB-231 triple-negative cell lines. cells, IC50 complex 35 ± 14 µg/mL, while 759 44 µg/mL 454 49 Our data that could be intracellular system cells. Cell viability assays evidenced reduced all lines time dose-dependent manner, significant sensitivity observed treated